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Relationship between parasitical inoculum and immunological parameters in experimental toxocariasis
J A Farjat1, M C Minvielle, B C Pezzani
1Cátedra de Microbiología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina.
Zentralblatt Fur Bakteriologie : International Journal of Medical Microbiology
|October 1, 1995
Summary
Toxocara canis larvae infect mice, reaching organs like the liver within hours. Higher egg doses lead to reinvasion and increased immune responses, including eosinophilia.
Area of Science:
- Veterinary Parasitology
- Immunology
- Infectious Diseases
Background:
- Toxocara canis is a common roundworm parasite.
- Toxocariasis affects various organs and elicits immune responses.
Purpose of the Study:
- To investigate the migration and organ distribution of Toxocara canis larvae in mice.
- To evaluate immunological parameters in response to varying infective doses.
Main Methods:
- Swiss female mice were inoculated with different doses of Toxocara canis eggs.
- Larval recovery, organ indexes (spleen, liver, lung), and blood eosinophilia were assessed post-infection.
Main Results:
- Toxocara canis larvae reached the liver between 10-15 hours post-infection.
- Reinvasion of liver and lungs occurred at 504 hours post-infection with >200 eggs.
- Larval brain arrival showed inverse relationship with inoculum dose; organ indexes and eosinophilia correlated with infection severity.
Conclusions:
- Infective dose influences Toxocara canis larval distribution and host immune response.
- Organ indexes and eosinophilia serve as indicators of infection intensity and immune reaction.