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Melanoma-in-transit presenting as panniculitis
J Cotton1, D J Armstrong, R Wedig
1Department of Pathology, Indiana University School of Medicine, Indianapolis, USA.
Journal of the American Academy of Dermatology
|November 12, 1998
Summary
This case highlights an extremely rare instance of malignant melanoma presenting as inflammatory skin metastasis. The patient developed unusual leg lesions mimicking infection, revealing a 20-year-old melanoma diagnosis and persistent local recurrence.
Area of Science:
- Dermatology
- Oncology
Background:
- Malignant melanoma can rarely present as inflammatory skin metastases.
- Early diagnosis and treatment are crucial for melanoma prognosis.
Observation:
- A patient presented with right leg lesions initially misdiagnosed as infectious.
- Lesions persisted despite antibiotic treatment, prompting biopsy.
- Biopsy revealed atypical S-100 positive cells in dermal vessels.
Findings:
- The patient had a history of a pigmented lesion removed 20 years prior, confirmed as malignant melanoma (3.2 mm depth).
- Despite lymph node dissection and chemotherapy, the patient experienced recurrent local disease.
- This case demonstrates an unusual clinical presentation and prolonged disease progression interval.
Implications:
- Highlights the importance of considering rare metastatic presentations in dermatology.
- Underscores the potential for late recurrence in malignant melanoma.
- Suggests the need for vigilance in long-term follow-up for melanoma survivors.