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Related Experiment Videos

Garlic extract therapy in children with hypercholesterolemia

B W McCrindle1, E Helden, W T Conner

  • 1Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Ontario, Canada.

Archives of Pediatrics & Adolescent Medicine
|November 12, 1998
PubMed
Summary
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Garlic extract therapy did not significantly lower cholesterol in children with familial hyperlipidemia. This randomized trial found no significant improvements in cardiovascular risk factors, indicating it

Area of Science:

  • Pediatric Cardiology
  • Nutraceutical Research
  • Clinical Trials

Background:

  • Familial hyperlipidemia is a significant risk factor for premature cardiovascular disease in children.
  • Alternative therapies, including herbal supplements like garlic extract, are explored for managing pediatric hyperlipidemia.
  • Evidence for the efficacy and safety of garlic extract in pediatric populations remains limited.

Purpose of the Study:

  • To evaluate the efficacy and safety of garlic extract in treating hypercholesterolemia in pediatric patients.
  • To determine the impact of garlic extract on fasting lipid profiles and other cardiovascular risk factors in children.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Thirty pediatric patients (aged 8-18 years) with familial hyperlipidemia participated.

Related Experiment Videos

  • Participants received either garlic extract (300 mg, 3 times daily) or a placebo for 8 weeks.

    • Main Results:

    • Garlic extract showed no significant effect on total cholesterol or low-density lipoprotein cholesterol levels.
    • No significant changes were observed in high-density lipoprotein, triglycerides, apolipoprotein B-100, lipoprotein (a), fibrinogen, homocysteine, or blood pressure.
    • A statistically significant, but small, increase in apolipoprotein A-I was noted, with no difference in adverse events between groups.

    Conclusions:

    • Garlic extract therapy is not effective in significantly altering cardiovascular risk factors in pediatric patients with familial hyperlipidemia.
    • The study did not identify any significant adverse effects associated with garlic extract use in this population.
    • Further research may be needed to explore other potential benefits or specific subgroups, but current evidence does not support its use for this condition.