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Related Experiment Videos

Garlic extract therapy in children with hypercholesterolemia

B W McCrindle1, E Helden, W T Conner

  • 1Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Ontario, Canada.

Archives of Pediatrics & Adolescent Medicine
|November 12, 1998
PubMed
Summary

Garlic extract therapy did not significantly lower cholesterol in children with familial hyperlipidemia. This randomized trial found no significant improvements in cardiovascular risk factors, indicating it

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Area of Science:

  • Pediatric Cardiology
  • Nutraceutical Research
  • Clinical Trials

Background:

  • Familial hyperlipidemia is a significant risk factor for premature cardiovascular disease in children.
  • Alternative therapies, including herbal supplements like garlic extract, are explored for managing pediatric hyperlipidemia.
  • Evidence for the efficacy and safety of garlic extract in pediatric populations remains limited.

Purpose of the Study:

  • To evaluate the efficacy and safety of garlic extract in treating hypercholesterolemia in pediatric patients.
  • To determine the impact of garlic extract on fasting lipid profiles and other cardiovascular risk factors in children.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted.
  • Thirty pediatric patients (aged 8-18 years) with familial hyperlipidemia participated.

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  • Participants received either garlic extract (300 mg, 3 times daily) or a placebo for 8 weeks.

    • Main Results:

    • Garlic extract showed no significant effect on total cholesterol or low-density lipoprotein cholesterol levels.
    • No significant changes were observed in high-density lipoprotein, triglycerides, apolipoprotein B-100, lipoprotein (a), fibrinogen, homocysteine, or blood pressure.
    • A statistically significant, but small, increase in apolipoprotein A-I was noted, with no difference in adverse events between groups.

    Conclusions:

    • Garlic extract therapy is not effective in significantly altering cardiovascular risk factors in pediatric patients with familial hyperlipidemia.
    • The study did not identify any significant adverse effects associated with garlic extract use in this population.
    • Further research may be needed to explore other potential benefits or specific subgroups, but current evidence does not support its use for this condition.