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[Isoimmune antibody formation after blood transfusions]
During February 1973 to October 1974 950 inpatients of the Department of Surgery, Erlangen, were tested for the presence of iso-antibodies before and after blood transfusions. Irregular antibodies were demonstrable in 0.95% of the patients before they received a blood transfusion. In 2.73% of the cases blood transfusion resulted in sensitization with the formation of specific blood group antibodies. Identification of the 26 iso-antibodies showed a prevalence of anti-Kell and anti-E (7 cases each). In view of the frequent occurrence of these two antigens tests for their presence are advisable before a blood transfusion is given. Persons who are re-admitted to hospital should also be tested to the presence of irregular antibodies to ensure that sensitization has not occurred during the intervening period.
During February 1973 to October 1974 950 inpatients of the Department of Surgery, Erlangen, were tested for the presence of iso-antibodies before and after blood transfusions. Irregular antibodies were demonstrable in 0.95% of the patients before they received a blood transfusion. In 2.73% of the cases blood transfusion resulted in sensitization with the formation of specific blood group antibodies. Identification of the 26 iso-antibodies showed a prevalence of anti-Kell and anti-E (7 cases each). In view of the frequent occurrence of these two antigens tests for their presence are advisable before a blood transfusion is given. Persons who are re-admitted to hospital should also be tested to the presence of irregular antibodies to ensure that sensitization has not occurred during the intervening period.