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Time-dependent changes in norepinephrine-induced left ventricular dysfunction and histopathologic condition

F D Allman1, W Herold, F J Bosso

  • 1Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|November 12, 1998
PubMed
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High doses of norepinephrine cause temporary left ventricular (LV) dysfunction in rabbits. This cardiac dysfunction is reversible, with normal LV systolic function returning by day 4, despite ongoing inflammation.

Area of Science:

  • Cardiology
  • Pharmacology
  • Pathology

Background:

  • Sympathetic nervous system activation or high catecholamine concentrations can impair myocardial contractility and cause heart lesions.
  • Norepinephrine is a key catecholamine involved in cardiovascular regulation.

Purpose of the Study:

  • To investigate the reversibility of norepinephrine-induced left ventricular (LV) dysfunction over time.
  • To determine if there is a causal relationship between norepinephrine-induced cardiac dysfunction and observed histopathologic changes.

Main Methods:

  • Conscious New Zealand white rabbits received norepinephrine (10 microg bolus, then 2.5 microg/kg/min for 90 min) or saline control.
  • Left ventricular (LV) function was assessed immediately, on day 4, and on day 10 post-treatment.

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  • Histopathological analysis of left ventricular tissue was performed.

    • Main Results:

    • Immediate norepinephrine administration caused severe LV dysfunction and reduced compliance.
    • By day 4, LV function and compliance normalized, but inflammation was present in ventricular tissue.
    • By day 10, inflammation progressed with collagen deposition, while LV systolic function remained normal, though compliance decreased.

    Conclusions:

    • Norepinephrine-induced LV systolic dysfunction is reversible.
    • Histologic changes (inflammation, collagen deposition) and LV dysfunction are not causally linked in this model.