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Clocks regulating developmental processes

O Pourquié1

  • 1Laboratoire de Génétique et de Physiologie du Développement (LGPD), CNRS-INSERM-Université de la Méditerranée-AP de Marseille, France. pourquie@ibdm.univ-mrs.fr

Current Opinion in Neurobiology
|November 13, 1998
PubMed
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Developmental clocks, hypothetical embryonic timekeepers, may operate via oscillators or rate-limiting processes. Their precise mechanisms remain largely unknown despite evidence from key developmental events.

Area of Science:

  • Developmental Biology
  • Cellular Timing Mechanisms

Background:

  • The concept of developmental clocks proposes internal embryonic time-measuring devices.
  • Evidence for these clocks is derived from timing observed in key developmental events.
  • Examples include the midblastula transition, Hox gene regulation, and cell differentiation.

Purpose of the Study:

  • To explore the hypothetical mechanisms of developmental clocks.
  • To investigate the role of oscillators and rate-limiting processes in embryonic timing.
  • To synthesize current evidence suggesting the existence of developmental clocks.

Main Methods:

  • Review and synthesis of recent studies on embryonic timing.
  • Analysis of data related to the midblastula transition.
  • Examination of Hox cluster dynamics during organogenesis.

Related Experiment Videos

  • Investigation of oligodendrocyte progenitor differentiation timing.

    • Main Results:

    • Developmental clocks are hypothesized to function through either oscillatory mechanisms or rate-limiting processes.
    • Recent research provides indirect evidence for developmental clocks from multiple embryonic systems.
    • The precise molecular and cellular underpinnings of these timing mechanisms are not yet elucidated.

    Conclusions:

    • The existence of developmental clocks is supported by observations in diverse developmental contexts.
    • Further research is required to uncover the specific mechanisms governing embryonic timekeeping.
    • Understanding developmental clocks is crucial for comprehending developmental processes and potential disruptions.