Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PASting together the mammalian clock

D Whitmore1, P Sassone-Corsi, N S Foulkes

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP, Illkirch, France.

Current Opinion in Neurobiology
|November 13, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy.

Science advances·2020
Same author

Morphology of the Antenna of Hermetia illucens (Diptera: Stratiomyidae): An Ultrastructural Investigation.

Journal of medical entomology·2017
Same author

Studying the Evolution of the Vertebrate Circadian Clock: The Power of Fish as Comparative Models.

Advances in genetics·2016
Same author

Relaxed selective constraints drove functional modifications in peripheral photoreception of the cavefish P. andruzzii and provide insight into the time of cave colonization.

Heredity·2016
Same author

Ultrastructural Morphology of the Antenna and Maxillary Palp of Sarcophaga tibialis (Diptera: Sarcophagidae).

Journal of medical entomology·2016
Same author

Coupling circadian rhythms of metabolism and chromatin remodelling.

Diabetes, obesity & metabolism·2015
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

Researchers identified key mammalian circadian clock components, including Clock and bmal1, and cloned period genes. These findings suggest widespread circadian clock presence in mammalian cells.

Area of Science:

  • Chronobiology
  • Molecular biology
  • Genetics

Background:

  • The circadian clock regulates daily biological rhythms.
  • Key components of the fruit fly (Drosophila) circadian clock have been identified.
  • Recent advancements have focused on understanding the mammalian circadian clock.

Purpose of the Study:

  • To identify the initial components of the mammalian circadian clock.
  • To investigate the expression patterns of mammalian clock genes.

Main Methods:

  • Cloning of mammalian homologs of Drosophila period genes.
  • Analysis of gene expression in various mammalian tissues (in vivo).
  • Assessment of gene expression in immortalized cell cultures (in vitro).

Related Experiment Videos

Main Results:

  • Identification and cloning of Clock and bmal1 genes.
  • Cloning of three mammalian homologs of Drosophila period genes.
  • Demonstration of oscillating expression of the mammalian period gene in multiple tissues and cell lines.

Conclusions:

  • The identified genes (Clock, bmal1, period homologs) are crucial components of the mammalian circadian clock.
  • Oscillating expression of the period gene indicates the presence of a functional circadian clock mechanism.
  • The findings strongly suggest that most, if not all, mammalian cells possess an intrinsic circadian clock.