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[Sequential changes in diamine oxidase activity after burn]

J Li1, S Sun, L Xue

  • 1304th Hospital of People's Liberation Army, Beijing.

Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi = Zhonghua Zheng Xing Shao Shang Waikf [I.E. Waike] Zazhi = Chinese Journal of Plastic Surgery and Burns
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Burn injury increases plasma diamine oxidase (DAO) levels, indicating intestinal mucosa damage. Elevated DAO in blood may serve as a marker for gastrointestinal injury following burns.

Area of Science:

  • Biochemistry
  • Physiology
  • Medical Science

Context:

  • Burn injuries cause significant physiological stress.
  • Assessing organ damage post-burn is crucial for patient outcomes.
  • Diamine oxidase (DAO) is an enzyme involved in histamine metabolism.

Purpose:

  • To investigate sequential changes in plasma and intestinal diamine oxidase (DAO) levels after burn injury in animal models and human patients.
  • To determine if DAO levels can serve as a biomarker for intestinal mucosa injury post-burn.

Summary:

  • Plasma DAO levels significantly increased in burn patients from day 1 to 14, returning to normal by day 21.
  • Pigs showed elevated plasma DAO post-burn, significantly at 72 hours.
  • Scald rats exhibited increased plasma DAO and decreased intestinal DAO, suggesting mucosal release.

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Impact:

  • Findings suggest intestinal mucosa injury and DAO release into circulation occur after burn injury.
  • Plasma DAO activity shows potential as a marker for reflecting intestinal mucosa injury severity post-burn.
  • This research could lead to improved diagnostic tools for burn-related gastrointestinal complications.