[Studies on teratogenic effects of aluminum on intra uterine fetal development in mice]

Effects of oral administration of different doses of aluminum during pregnancy on intra uterine fetal development in mice were studied with experimental teratological methods. Results showed that over-intake of aluminum could lead obvious teratogenic and toxic effects on fetal development in mice. It could cause formation of encephalocele and dysostosis, intra uterine fetal growth retardation, and increase of embryo death rate, with a obvious dose-dependent relation. It suggests that excessive ingestion of aluminum may be one of the risk factors contributing to congenital neural tube defects, intra uterine fetal growth retardation and perinatal deaths.