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Updated: Jul 3, 2026
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
Published on: September 22, 2012
[Effects of "qing kai ling" injection on experimental cerebral hematoma in rabbits]
1Department of Pathology, Beijing University of Traditional Chinese Medicine.
Objective:
To observe the effect of "Qingkailing" (QKL) on cerebral hematoma.
Methods:
The experimental cerebral hematoma models were produced by injecting autogenous clot in the rabbit. The influences of QKL on blood gas, brain index, contents of water, sodium, potassium, calcium, magnesium in brain tissues and changes of cerebrovascular permeability, histomorphology at the third day, seventh day, fourteenth day after cerebral hematoma were observed.
Results:
In the pathological group brain index and contents of water, sodium, calcium of brain tissue, ventilation of lung were increased progressively, cerebrovascular permeability were raised obviously, especially in the side of hematoma (right brain). After the forming of cerebral hematoma cerebral edema was reduced, brain index, contents of water, sodium, calcium in brain tissue and cerebrovascular permeability, hyperventilation were all less than pathological group and close to the control group.
Conclusion:
QKL was advantageous in the treatment of encephal edema induced by experimental cerebral hematoma.
