[Hypoglycemic effect of Rhodiola sachalinensis A. Bor. polysaccharides: comparison of administration in different...

When Rhodiola sachalinensis polysaccharides A and B (RSP A and RSP B) were intraperitoneally injected to mice at dosages of 50 mg/kg and 100 mg/kg, the result showed that RSP B was the effective hypoglycemic ingredient of Rhodiola sachalinensis. When mice were administrated in different ways, it was shown that RSP B did not possess significant hypoglycemic effect through absorption in the instestines. However, RSP B does possess significant hypoglycemic effect if administrated subcutaneously, intramuscularly, intraperitoneally and intravenously.