[Effect of hemin in treating hemorrhagic anemia and toxicity]
Related Experiment Video
Updated: Oct 27, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Aim:
To study the effect of hemin in treating hemorrhagic anemia and toxicity.
Methods:
Fifty rats with hemorrhagic anemia were randomly divided into 5 groups with different dosage of hemin (93, 168, 300 mg.kg-1.d-1), ferrous gluconate (FG 300 mg.kg-1.d-1), and water, ig for 7 d. Twenty mice fed with hemin (6.0 g.kg-1.d-1) in 24 h for observing acute toxicity effects. Long-term toxicity were observed in 80 rats given hemin (0.65, 1.3, 2.6 g.kg-1.d-1) in 3 months.
Results:
Hb of the rats of corresponding groups were 66-->121, 71-->141, 66-->148, 69-->140, and 67-->112 g.L-1. There were no adverse effects observed on acute toxicity test. No abnormalitis were found in hemogram, liver renal function test, and autopsy.
Conclusion:
Hemin had a better effect than FG and no adverse effect was found in hemin.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Hemorrhagic Stroke ll: Pathophysiology
Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Pharmaceutical Poisoning: Treatment Strategies
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...