Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maintenance therapy of depression

E S Paykel, A DiMascio, G L Klerman

    Pharmakopsychiatrie, Neuro-Psychopharmakologie
    |May 1, 1976
    PubMed
    Summary

    Continuing amitriptyline maintenance treatment for several months significantly reduces relapse in neurotic depression. Psychotherapy aids social adjustment in non-relapsed patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Which depressions are related to life stress?

    Acta neuropsychiatrica·2016
    Same author

    Treatment of unipolar major depression: Algorithms for pharmacotherapy.

    International journal of psychiatry in clinical practice·2014
    Same author

    Antidepressants: Their efficacy and place in therapy.

    Journal of psychopharmacology (Oxford, England)·2011
    Same author

    Melancholia.

    Journal of psychopharmacology (Oxford, England)·2011
    Same author

    Partial remission, residual symptoms, and relapse in depression.

    Dialogues in clinical neuroscience·2009
    Same author

    Do treated psychiatric patients become later community cases? A prospective cohort study.

    European psychiatry : the journal of the Association of European Psychiatrists·2006

    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Pharmacology

    Background:

    • Neurotic depression requires effective maintenance treatment strategies.
    • Initial treatment with amitriptyline shows promise for depressive symptom relief.

    Purpose of the Study:

    • To evaluate the efficacy of continued amitriptyline treatment versus early withdrawal.
    • To assess the impact of psychotherapy on social adjustment post-treatment.

    Main Methods:

    • A factorial study design was employed.
    • Patients received maintenance treatment with amitriptyline, withdrawn double-blind to placebo, or withdrawn overtly to no medication.
    • Individual psychotherapy was administered to a subset of participants.

    Main Results:

    • Continuation of amitriptyline significantly reduced early relapse and symptom recurrence compared to early withdrawal.
    • Psychotherapy improved social adjustment in patients who did not relapse.
    • Carbohydrate craving was the most notable side effect.

    Conclusions:

    • Routine continuation of tricyclic antidepressants for several months post-remission is recommended.
    • Psychotherapy can enhance social adjustment in recovered patients.
    • Maintenance therapy is crucial for sustained recovery in neurotic depression.

    Related Experiment Videos