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A sequence-specific splicing activator, tra2beta, is up-regulated in response to nerve injury
S Kiryu-Seo1, N Matsuo, A Wanaka
1Department of Anatomy, Asahikawa Medical college, Nishikagura 4-5-3-11, Asahikawa, 078-8510, Japan.
Abstract:
Tra2beta is the first mammalian protein which is proved to activate mRNA splicing in sequence-specific manner. Following hypoglossal nerve injury, the expression of Tra2beta mRNA was elevated in injured motoneurons transiently. The up-regulation of Tra2beta mRNA was observed from post-operative day 3 to 21. In addition to the nerve injury in PNS, a brain lesion in CNS also enhanced the expression of Tra2beta mRNA. The present study could be the first observation showing that an expression of the sequence-specific splicing activator is enhanced in neuronal cells in response to nerve injury, and indicates that Tra2beta may participate in the control of injury-specific splicing patterns in order to express molecules which are necessary for regeneration.