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Secretin and gastric lipase secretion
O Olsen1, M Wøjdemann, B Berner
1Department of Surgery D, Glostrup Hospital, University of Copenhagen, Sweden.
Digestion
|November 14, 1998
Summary
Secretin does not affect the amount of gastric lipase stimulated by gastrin. However, secretin increases gastric lipase
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Gastric lipase secretion is stimulated by gastrin.
- The regulatory role of secretin on gastric lipase remains unclear.
Purpose of the Study:
- To investigate the effect of exogenous secretin on gastrin-stimulated gastric lipase secretion.
- To determine if secretin influences gastric lipase quantity and lipolytic activity.
Main Methods:
- Seven healthy individuals participated in the study.
- Exogenous secretin was infused to observe its effect on gastrin-17-stimulated gastric lipase.
- Gastric lipase secretion was quantified using ELISA and lipolytic activity measured by kinetic assay.
Main Results:
- Gastrin significantly stimulated both the quantity and lipolytic activity of gastric lipase.
- Secretin infusion led to increased lipolytic activity.
- Acid secretion decreased in response to secretin infusion.
Conclusions:
- Postprandial concentrations of secretin do not alter gastrin-stimulated quantitative gastric lipase secretion.
- Secretin enhances gastric lipase's lipolytic activity by inhibiting acid secretion.