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The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments
1Laboratoire d'ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France.
Experimental and Clinical Immunogenetics
|November 14, 1998
Summary
This report details human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments, presenting comprehensive tables of germline gene and allele information. These resources are crucial for understanding the human immune system
Area of Science:
- Immunogenetics
- Molecular Biology
- Genomics
Background:
- The human immunoglobulin kappa locus is critical for adaptive immunity.
- Detailed characterization of germline genes and segments is essential for understanding immune repertoire diversity.
- Previous reports in the 'IMGT Locus on Focus' series have provided foundational data.
Purpose of the Study:
- To present a comprehensive catalog of human germline IGKV genes and IGKJ segments.
- To provide detailed tables of IGKV and IGKJ alleles.
- To make this data accessible through the IMGT database.
Main Methods:
- Compilation and curation of existing data on human IGKV and IGKJ genes and segments.
- Organization of data into five distinct tables.
- Publication of tables on the IMGT Marie-Paule page.
Main Results:
- The report includes tables on the number of human germline IGKV genes at 2p12 and their potential repertoire.
- A detailed human germline IGKV gene table and human IGKV allele table are provided.
- Comprehensive human germline IGKJ table and human IGKJ allele table are presented.
Conclusions:
- This work consolidates essential genetic information for human IGKV and IGKJ segments.
- The presented data serves as a valuable resource for immunogenetic research.
- Accessibility via the IMGT database facilitates further scientific investigation.