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Diffuse neuroendocrine system: structural and functional effects of radiation injury to amine precursor uptake and
I M Kvetnoy1, V V Yuzhakov, A O Molotkov
1Laboratory of Experimental Pathomorphology, Medical Radiological Research Center (MRRC) of Russian Academy of Medical Science (RAMS), Obninsk, Russia.
Abstract:
The paper presents a review of the results obtained by the authors on the study of external (gamma) and internal (I-131) radiation effects on the functional morphology and linkage of the diffuse neuroendocrine system (DNES) and amine precursor uptake and decarboxylation (APUD) cells of the stomach and duodenum. The investigations performed enabled us to determine that the morphological changes noted in APUD cells had a dose and time dependency. The present study supports the point of view that the radiation initiates serotonin release from APUD cells, which appears to initiate the mechanism of early postirradiation dysfunctions of the gastrointestinal tract and the subsequent adaptive response of DNES. Analysis of our results, together with a review of the literature, indicates that APUD cells actively participate both in pathogenesis of radiation injury and development of organ and tissue radiosensitivity.