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Related Experiment Videos

Ehrlichia spp. in cervids from California

J E Foley1, J E Barlough, R B Kimsey

  • 1Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis 95616, USA.

Journal of Wildlife Diseases
|November 14, 1998
PubMed
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Cervids like deer and elk may play a role in maintaining Ehrlichia equi, a cause of human granulocytic ehrlichiosis (HGE), in California. Studies found E. equi in elk and related Ehrlichia species in deer, suggesting their importance in pathogen cycles.

Area of Science:

  • Veterinary Pathology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Human granulocytic ehrlichiosis (HGE) and human monocytic ehrlichiosis (HME) are emerging tick-borne diseases.
  • Cervids, including deer and elk, are potential reservoirs for tick-borne pathogens.

Purpose of the Study:

  • To investigate the role of cervids in the maintenance of Ehrlichia species, including those causing HGE, in California.
  • To determine the seroprevalence and PCR prevalence of Ehrlichia species in mule deer, black-tailed deer, and tule elk.

Main Methods:

  • Blood samples were collected from cervids between 1992-1997.
  • Assays included polymerase chain reaction (PCR), DNA sequencing, and serology.
  • Ehrlichia equi isolates were propagated in cell cultures.

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Main Results:

  • 17% of elk were seropositive for Ehrlichia equi, while deer were seronegative.
  • PCR detected Ehrlichia-like species in 38% of deer and E. equi in 5% of deer.
  • PCR detected E. equi in 31% of elk.
  • DNA sequencing confirmed E. equi in elk and related Ehrlichia species in deer, closely related to strains found in other states.

Conclusions:

  • Cervids, particularly elk, may be significant reservoirs for Ehrlichia equi in California.
  • These findings suggest cervids contribute to the natural enzootic cycle of E. equi in the region.
  • Further research is needed to fully elucidate the role of cervids in Ehrlichia transmission dynamics.