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Updated: Jul 24, 2026

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
Published on: April 1, 2018
Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology
J B Hale1, J A Hoeppner, M B DeWitt
1School of Psychology Program, Moorhead State University, MN 56563, USA.
Abstract:
Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.
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To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.