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Related Experiment Video

Updated: Jul 24, 2026

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

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Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology

J B Hale¹, J A Hoeppner, M B DeWitt

¹School of Psychology Program, Moorhead State University, MN 56563, USA.

Journal of Learning Disabilities

|November 14, 1998

Summary

This study introduces a method to assess how methylphenidate (MPH) affects attention-deficit/hyperactivity disorder (ADHD) symptoms and cognition in individuals. Analyzing dose-response relationships can improve MPH treatment and long-term outcomes.

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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Double-blind placebo-controlled trials are standard for evaluating methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD).
Limited research has explored MPH's impact on cognitive deficits in ADHD using these trial designs.

Observation:

This article details a technique to assess behavioral and cognitive dose-response relationships for MPH.
The method allows for single-subject level analysis, providing granular insights into treatment effects.

Findings:

Case study results and multivariate analyses indicate the utility of this systematic evaluation approach.
The findings suggest a link between evaluating dose-response relationships and treatment effectiveness.

Implications:

Systematic assessment of MPH dose-response can lead to more precise medication titration.
Improved titration may enhance the long-term efficacy of multimodal treatment for ADHD.
This approach could refine how MPH is prescribed for both behavioral and cognitive symptoms in ADHD.