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Related Experiment Videos

Malaria Prophylaxis in Different Age Groups

Mittelholzer1, Wall, Steffen

  • 1Pharmaceuticals Division, Business Development & Strategic Marketing, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Journal of Travel Medicine
|December 1, 1996
PubMed
Summary

Senior travelers tolerate malaria chemoprophylaxis as well as younger adults. This study found senior travelers experienced lower rates of malaria and travel-associated illnesses, with comparable side effect profiles.

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Area of Science:

  • Tropical medicine
  • Traveler's health
  • Epidemiology

Background:

  • Senior travelers may face increased health risks in malaria-endemic regions.
  • Existing data on malaria chemoprophylaxis effectiveness and tolerability in older adults is limited.
  • This study addresses the perceived health risks for senior visitors to malaria-endemic countries.

Purpose of the Study:

  • To compare the effectiveness and tolerability of malaria chemoprophylaxis in senior travelers (>=60 years) versus younger travelers (20-59 years).
  • To analyze demographic and travel data to assess health outcomes in different age groups.
  • To evaluate the incidence of malaria and travel-associated illnesses, as well as side effects of prophylaxis.

Main Methods:

  • Utilized the "Malpro 2" database, comprising over 100,000 traveler questionnaires from East Africa to Europe (July 1988-December 1991).

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  • Compared data from 9106 senior travelers (>=60 years) with 84,562 younger travelers (20-59 years).
  • Employed logistic regression to adjust for age, sex, prophylaxis, and duration of stay.

    • Main Results:

    • Malaria incidence was lower in senior travelers (1/1000) compared to younger travelers (2.2/1000).
    • Senior travelers reported significantly fewer travel-associated illnesses (7.0% vs 13.6%).
    • Side effect rates from malaria prophylaxis were comparable, with slightly lower rates in seniors (9.7% vs 15.5%).

    Conclusions:

    • Senior travelers tolerate malaria chemoprophylaxis and tropical travel at least as well as younger travelers.
    • The study suggests that age is not a significant factor in the tolerability or effectiveness of malaria prevention.
    • Findings support current recommendations for malaria chemoprophylaxis in older adult travelers.