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Related Experiment Videos

Prostate-specific membrane antigen expression in normal and malignant human tissues

D A Silver1, I Pellicer, W R Fair

  • 1Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|January 1, 1997
PubMed
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Prostate-specific membrane antigen (PSMA) is found in prostate tissue and some normal tissues. PSMA is present in most prostate cancers but also neoexpressed in tumor vasculature, suggesting potential therapeutic applications.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunohistochemistry

Background:

  • Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein with folate hydrolase activity.
  • PSMA is primarily produced by prostatic epithelium but also found in some extraprostatic tissues.
  • Its expression pattern and functional significance beyond prostate cancer require further elucidation.

Purpose of the Study:

  • To extensively characterize the expression pattern of PSMA in a wide range of normal and malignant human tissues using immunohistochemistry.
  • To investigate the correlation between PSMA expression and tumor differentiation in prostate cancer.
  • To explore the potential role of PSMA neoexpression in tumor angiogenesis and neovasculature.

Main Methods:

  • Extensive immunohistochemical analysis of a diverse panel of well-characterized normal and malignant human tissues.

Related Experiment Videos

  • Evaluation of PSMA protein levels and localization within different cellular compartments and tissue types.
  • Correlation of PSMA immunostaining with tumor grade and metastatic status in prostate cancer samples.

    • Main Results:

    • PSMA was detected in prostatic epithelium, duodenal mucosa, proximal renal tubules, and a subset of colonic neuroendocrine cells.
    • PSMA immunostaining was observed in 33/35 primary prostate adenocarcinomas and 7/8 lymph node metastases.
    • Intense PSMA staining was noted in the endothelial cells of tumor-associated capillary vessels in renal cell carcinoma, transitional cell carcinoma, and colon carcinoma.
    • PSMA expression decreased in advanced prostate cancer, correlating with lower tumor differentiation.

    Conclusions:

    • PSMA exhibits a restricted but diverse expression pattern in normal tissues.
    • PSMA is highly expressed in most prostate cancers, but its expression diminishes with advanced disease.
    • Neoexpression of PSMA in tumor neovasculature suggests potential for targeting tumor angiogenesis and specific delivery to tumor sites.