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Treatment-related parameters predicting efficacy of Lym-1 radioimmunotherapy in patients with B-lymphocytic
K R Lamborn1, G L DeNardo, S J DeNardo
1Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco Medical Center, San Francisco, California 94143, USA.
Abstract:
This study was designed to evaluate dosimetric, pharmacokinetic, and other treatment-related parameters as predictors of outcome in patients with advanced B-lymphocytic malignancies. Fifty-seven patients were treated with radiolabeled Lym-1 antibody in early phase trials between 1985 and 1994. Logistic regression and proportional hazards models were used to evaluate treatment parameters for their ability to predict outcome, taking into account patient risk group based on Karnofsky performance status and serum lactic dehydrogenase. The occurrence of a partial or complete response (31 of 57 patients) and development of human antimouse antibody (HAMA) predicted improved survival using a time-dependent proportional hazards model. The final multivariate model for survival with parameters significant at P