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Related Experiment Videos

PAX5 expression correlates with increasing malignancy in human astrocytomas

E T Stuart1, C Kioussi, A Aguzzi

  • 1Department of Molecular Cell Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Göttingen, Germany.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 1, 1995
PubMed
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Increased expression of PAX5, a gene on chromosome 9p, is linked to the progression of human astrocytic tumors. This finding suggests PAX5 may play a role in promoting brain tumor malignancy.

Area of Science:

  • Neuro-oncology
  • Molecular genetics
  • Cancer biology

Background:

  • Chromosome 9p rearrangements are late events in astrocytoma progression.
  • PAX5 gene is located at chromosome 9p13.
  • Murine Pax5 is not expressed in the forebrain.

Purpose of the Study:

  • To investigate PAX5 expression in primary human astrocytic tumors.
  • To determine the correlation between PAX5 expression and tumor grade.
  • To explore the relationship between PAX5 and oncogene expression in astrocytomas.

Main Methods:

  • Studied PAX5 expression in astrocytomas (WHO grades II-IV).
  • Examined co-expression of PAX5 with oncogenes (myc, fos, jun).
  • Assessed epidermal growth factor receptor (EGFR) expression in relation to PAX5.

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Main Results:

  • PAX5 expression was elevated in human astrocytomas originating in the forebrain.
  • PAX5 expression was confined to cells co-expressing myc, fos, or jun.
  • High PAX5 positivity correlated with high EGFR expression in glioblastoma multiforme.

Conclusions:

  • Inappropriate PAX5 expression may promote astrocytoma malignancy.
  • PAX5 may be a potential biomarker for astrocytoma progression.
  • The study highlights the role of PAX5 in human brain tumor development.