Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomerase activity in human bladder cancer

Y Lin1, H Miyamoto, K Fujinami

  • 1Department of Urology, Yokohama City University, School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama 236, Japan.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 1, 1996
PubMed
Summary

Telomerase activity is highly prevalent in human bladder tumors, correlating with advanced stages and deeper invasion. This enzyme

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biodegradable scleral implant for intravitreal controlled release of fluconazole.

Current eye research·1997
Same author

Ki-67 labeling indices in non-small cell lung cancer: comparison between image cytometry and flow cytometry.

Cytometry·1997
Same author

Analysis of p21Waf1/Cip1 expression in normal, premalignant, and malignant cells during the development of human lung adenocarcinoma.

The American journal of pathology·1997
Same author

Monoclonal antibodies against pig ovarian follicular granulosa cells induce apoptotic cell death in cultured granulosa cells.

The Journal of veterinary medical science·1997
Same author

Lectin histochemistry in rat liver fibrosis induced by heterologous serum sensitization.

The Journal of veterinary medical science·1997
Same author

[Serological differences in Helicobacter pylori].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·1997

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Telomere length and telomerase activity influence cell proliferation in normal and malignant cells.
  • Telomerase expression is linked to cellular immortality in tumors.
  • Telomerase activity may serve as a marker for tumor production.

Purpose of the Study:

  • To investigate telomerase activity in human bladder cancers and associated tissues.
  • To correlate telomerase expression with clinicopathological features of bladder tumors.

Main Methods:

  • Analysis of telomerase activity using a PCR-based telomeric repeat amplification protocol assay.
  • Examination of 40 human bladder cancers, 7 normal tissues, and 2 dysplastic bladder epithelia.

Related Experiment Videos

Main Results:

  • Telomerase activity was detected in 97.5% of bladder tumors.
  • Normal tissues showed no telomerase activity; one dysplastic tissue had low activity.
  • High telomerase activity strongly correlated with advanced pathological grade and deep tumor invasion.

Conclusions:

  • Telomerase activity is a significant indicator in human bladder cancer.
  • Its expression is associated with tumor progression and invasiveness.
  • Telomerase activity may be a crucial component in bladder cancer development.