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Effects of ondansetron on postoperative emesis in Chinese children

L K Chen, S Z Fan, C H Huang

    Acta Anaesthesiologica Sinica
    |November 17, 1998
    PubMed

    Insights

    Ondansetron significantly reduced postoperative nausea and vomiting (PONV) in pediatric patients undergoing surgery. This study confirms ondansetron

    Area of Science:

    • Anesthesiology
    • Pediatric Surgery
    • Pharmacology

    Background:

    • Postoperative nausea and vomiting (PONV) is a frequent complication following general anesthesia.
    • Ondansetron, a selective serotonin 5-HT3 receptor antagonist, is recognized for its efficacy in managing PONV.
    • Limited clinical data exists on ondansetron's use for PONV prevention in Taiwan.

    Purpose of the Study:

    • To assess the effectiveness and safety of ondansetron in preventing PONV in pediatric patients in Taiwan.
    • To evaluate ondansetron's role in managing PONV in children undergoing specific surgical procedures.

    Main Methods:

    • A prospective, randomized, placebo-controlled trial involving 80 pediatric patients (2-12 years) undergoing herinorrhaphy.
    • Patients received either ondansetron (0.1 mg/kg) or a saline placebo intravenously.
    • Data on emesis episodes and complications were collected via parental questionnaires over a 24-hour postoperative period.

    Main Results:

    • The incidence of postoperative emesis was substantially lower in the ondansetron group (10%) compared to the placebo group (55%).
    • Emetic symptom severity was also milder in children who received ondansetron.
    • No significant differences in other postoperative complications were observed between the groups.

    Conclusions:

    • Intravenous ondansetron at 0.1 mg/kg is a safe and effective prophylactic agent against postoperative emesis in pediatric patients undergoing herinorrhaphy.
    • Findings support the use of ondansetron for PONV prevention in this specific pediatric population in Taiwan.
    Abstract

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