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Updated: Aug 10, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
[Hypertension-induced organ damage]
1Krankenhaus Neukölln, Innere Medizin I, Berlin.
Insights
New guidelines define normal blood pressure as below 130/85 mmHg, necessitating adjusted treatment targets. Early diagnosis and consistent management of hypertension are crucial to prevent organ damage.
Area of Science:
- Cardiology and Public Health
- Hypertension research and clinical practice
Context:
- Current guidelines previously accepted <140/90 mmHg as normal resting blood pressure.
- Recent recommendations lower the normotension threshold to <130/85 mmHg.
Purpose:
- To highlight the shift in hypertension definition and its implications for therapeutic targets.
- To emphasize the need for early diagnosis and improved antihypertensive treatment strategies.
Summary:
- Elevated blood pressure accelerates arteriosclerosis, leading to organ damage (brain, heart, kidney) and conditions like left ventricular hypertrophy and hypertensive encephalopathy.
- Echocardiography aids in early detection of hypertension-induced organ damage.
- Effective antihypertensive therapy is vital for preventing or mitigating these complications.
Impact:
- Adjusting therapeutic targets is essential to align with new normotension ranges.
- Reducing the high prevalence of undiagnosed and undertreated hypertension is critical.
- Implementing specific proposals can decrease avoidable hypertension-related organ damage and promote public health awareness.
Abstract:
Until now, an occasional blood pressure of below 140 mmHg systolic and less than 90 mmHg diastolic at rest has been regarded as normal. However, the most recent recommendations set the range for normotension lower: below 130/85 mmHg. Therapeutic targets will have to be adjusted accordingly. Raised diastolic and/or systolic blood pressure accelerates the process of arteriosclerosis and causes baromechanical effects. These result in disturbances of organ perfusion (brain, heart, kidney, peripheral organs) and left ventricular hypertrophy, cardiac failure, haemorrhagic insult and hypertensive encephalopathy. Echocardiography is particularly well suited for revealing and quantifying the results of hypertension at an early stage. Prompt, adequate antihypertensive therapy prevents or decreases hypertension-induced organ damage. Early diagnosis of hypertension and consistent blood pressure normalisation are, therefore, indispensable. The proportion of undiagnosed and inadequately treated hypertension patients is too high, in fact it is clearly increasing. The author presents specific proposals for improving antihypertensive treatment in order to reduce or prevent avoidable hypertension-induced organ damage. Above all, society must heighten its awareness of health and sharpen its own sense of responsibility.
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