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[Cancer of the kidney in the adult]
J P Delord1, J Alexandre, C Chevreau
1Centre Claudius-Regaud, Service d'oncologie médicale, Toulouse.
Abstract:
Renal cell carcinoma is a frequent disease. Recently, its incidence has been rising. Kidney tumors are detected more frequently by the newer radiologic techniques, but the diagnosis is steel difficult and occurs often late in the natural history of the disease. A high proportion of patients have metastases at diagnosis or after initial surgery. Many types of systemic therapy have been studied but resistance to radiotherapy and chemotherapy is the rule. There is a potential role for immunomodulation in the inhibition of tumor growth but clinical issue remain uncertain. In this review we discuss recent developments in epidemiology, histologic classification, tumor biology, methods of diagnosis, surgical techniques and immunotherapy for patients with metastatic disease.
Insights
Renal cell carcinoma (kidney cancer) incidence is rising, with late diagnoses and frequent metastases. Current treatments show limited efficacy, but immunotherapy offers potential for managing advanced kidney cancer.
Area of Science:
- Oncology
- Urology
Context:
- Renal cell carcinoma (kidney cancer) is a significant health concern with increasing incidence.
- Early detection remains challenging despite advances in radiologic techniques.
- Metastasis at diagnosis or post-surgery is common in kidney cancer patients.
Purpose:
- To review recent advancements in renal cell carcinoma (kidney cancer) management.
- To discuss epidemiology, classification, biology, diagnosis, surgery, and immunotherapy for metastatic kidney cancer.
Summary:
- Recent trends show a rise in renal cell carcinoma (kidney cancer) incidence.
- Diagnosis is often delayed, and resistance to conventional therapies (radiotherapy, chemotherapy) is prevalent.
- Immunotherapy presents a potential avenue for inhibiting tumor growth in advanced kidney cancer, though clinical outcomes require further investigation.
Impact:
- Provides a comprehensive overview of current knowledge and emerging strategies for renal cell carcinoma (kidney cancer).
- Highlights the challenges in treating metastatic kidney cancer and the potential of novel therapeutic approaches like immunotherapy.
- Informs clinicians and researchers on the latest developments in kidney cancer research and patient care.