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Related Experiment Video

Updated: Jul 24, 2026

Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats

Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats

Published on: January 6, 2023

Diffuse neurofibroma of the ankle

I Beggs¹, H M Gilmour, R M Davie

¹Department of Clinical Radiology, Royal Infirmary of Edinburgh, UK.

Clinical Radiology

|November 17, 1998

Summary

Diffuse neurofibroma imaging shows characteristic infiltration patterns on MRI. Post-gadolinium T1-weighted images are crucial for visualizing tumor enhancement and tissue strands.

Area of Science:

Radiology
Oncology
Pathology

Background:

Diffuse neurofibroma is a rare neoplastic proliferation of peripheral nerve sheath cells.
Accurate diagnosis relies on correlating imaging with histological findings.

Observation:

Computed tomography (CT) reveals diffuse infiltration of subcutaneous and deep fat, appearing isodense to muscle.
Magnetic resonance imaging (MRI) demonstrates extensive infiltration of fat, enveloping structures without bone involvement.
Superficial masses show homogeneous enhancement post-gadolinium, while deep infiltration exhibits a reticular pattern.

Findings:

Post-gadolinium T1-weighted MRI sequences are optimal for visualizing tumor enhancement and non-enhancing hypointense soft tissue strands.
MRI effectively delineates the extent of infiltration, distinguishing it from surrounding tissues.

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Advanced imaging techniques like MR angiography and Doppler ultrasound can reveal vascular abnormalities.

Implications:

MRI, particularly with post-gadolinium T1-weighted sequences, provides a characteristic imaging signature for diffuse neurofibroma.
This characteristic appearance aids in accurate diagnosis and surgical planning.
Further research can explore the role of advanced imaging in differentiating benign from malignant neurofibromas.