Effects of undrugged partners on scopolamine-induced changes in activity and sociability

One group of 6 rats was injected with saline, one with 1.0 mg/Kg scopolamine (D/D) and two others had half the members in each injected with saline and half with scopolamine (S/D). Each was tested in a 36 X 36 in. open field for 10 min. The frequency of ambulation, rearing, social contacts, and the shortest and perimeter distances between rats were found. The presence of the partners in the S/D groups eliminated most of the scopolamine-induced changes found in the D/D group, showing that the nature of the social environment affects drug-induced changes in activity and sociability.