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Development of a scheme for genotyping Helicobacter pylori based on allelic variation in urease subunit genes
R J Owen1, E R Slater, J Xerry
1Laboratory of Enteric Pathogens, Central Public Health Laboratory, London, United Kingdom. rowen@phls.co.uk
Journal of Clinical Microbiology
|November 18, 1998
Abstract:
Helicobacter pylori urease subunit genes in 383 isolates from 10 countries were investigated by PCR-restriction fragment length polymorphism (HaeIII) analysis. Eighty-two different ureAB profiles were documented by reference to known sequences. Variation among 51% of strains was accounted for by 10 predominant patterns, which provided a unique framework for categorizing isolates with geographically diverse origins.