Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methacholine bronchial hyperresponsiveness in chronic sinusitis

M Okayama1, H Iijima, S Shimura

  • 1Cardiovascular Disease Center, Tohoku University School of Medicine, Sendai, Japan.

Respiration; International Review of Thoracic Diseases
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination therapy of ustekinumab and immunomodulator for inflammatory bowel disease: concerns about the different results observed between two meta-analyses.

Journal of gastroenterology and hepatology·2023
Same author

Uncovering the "riddle of femininity" in osteoarthritis: a systematic review and meta-analysis of menopausal animal models and mathematical modeling of estrogen treatment.

Osteoarthritis and cartilage·2023
Same author

Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score matching analysis.

ESMO open·2022
Same author

Impact of technically qualified surgeons on laparoscopic colorectal resection outcomes: results of a propensity score-matching analysis.

BJS open·2020
Same author

Weak influence of near-surface layer on solar deep convection zone revealed by comprehensive simulation from base to surface.

Science advances·2019
Same author

Trunk movement asymmetry associated with pain, disability, and quadriceps strength asymmetry in individuals with knee osteoarthritis: a cross-sectional study.

Osteoarthritis and cartilage·2018
Same journal

Real-world long-term efficacy of chemoimmunotherapy in advanced stage small cell lung cancer.

Respiration; international review of thoracic diseases·2026
Same journal

Residual AHI Measurement from PAP Devices Versus Home Polygraphy: A Method Comparison Study Using Real World Data.

Respiration; international review of thoracic diseases·2026
Same journal

Unveiling Sex Differences in Severe Acute COPD Exacerbations requiring ICU admission: Evidence from a French Cohort.

Respiration; international review of thoracic diseases·2026
Same journal

Intrapleural Fibrinolytics use in Children with Pleural Empyema: Safe and Effective.

Respiration; international review of thoracic diseases·2026
Same journal

Learning Curve for Transbronchial Lung Cryobiopsy in Interstitial Lung Disease Diagnosis: A Multicenter Experience.

Respiration; international review of thoracic diseases·2026
Same journal

Follow-Up Care After Adult Lung Transplantation: Summary of an Evidence-Based Clinical Practice Guideline for German-Speaking Countries.

Respiration; international review of thoracic diseases·2026
See all related articles

Chronic sinusitis (CS) can cause bronchial hyperresponsiveness (BH) in individuals without lower airway disease. Treating CS effectively reduces this BH, improving respiratory health.

Area of Science:

  • Respiratory Medicine
  • Otolaryngology
  • Pulmonology

Background:

  • Chronic sinusitis (CS) may worsen lower airway diseases like asthma and bronchitis.
  • Bronchial hyperresponsiveness (BH) in CS patients without lower airway disease is not well understood.
  • The impact of CS treatment on BH requires further investigation.

Purpose of the Study:

  • To investigate bronchial hyperresponsiveness (BH) in chronic sinusitis (CS) patients without lower airway disease.
  • To compare BH in CS patients with those suffering from stable asthma, chronic bronchitis, or allergic rhinitis.
  • To evaluate the effect of endoscopic sinus surgery on BH in CS patients.

Main Methods:

  • Methacholine (MCh) challenge test was used to assess BH in 42 CS patients, 50 with asthma, 50 with chronic bronchitis, and 40 with allergic rhinitis.

Related Experiment Videos

  • BH was defined as a minimum dose (Dmin) <50 units of MCh, indicating a decrease in respiratory conductance.
  • BH was assessed before and after endoscopic sinus surgery in 7 CS patients.

    • Main Results:

    • 71% of CS patients exhibited BH, irrespective of CS severity, duration, or atopic status.
    • BH prevalence and degree in CS patients were comparable to those with simple chronic bronchitis or allergic rhinitis, but less than in asthma patients.
    • Endoscopic sinus surgery significantly reduced BH (p < 0.01) in CS patients, alongside improvements in nasal symptoms and sinus lesions.

    Conclusions:

    • Chronic sinusitis itself induces bronchial hyperresponsiveness (BH) to a degree similar to simple chronic bronchitis and allergic rhinitis.
    • BH in CS patients occurs independently of clinical background factors.
    • Effective treatment of CS, including surgery, can significantly decrease BH.