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DCC and netrins
1Department of Molecular and Medical Genetics, Faculty of Medicine, University of Toronto, Canada. culotti@mshri.on.ca
Current Opinion in Cell Biology
|November 18, 1998
Abstract:
Recent advances highlight the versatility and complexity of this highly conserved axon and cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly and mouse all suggest that netrins play local as well as long-range roles in guidance. Evidence from multiple sources also indicates that the netrin receptor DCC can mediate both attractive and repulsive responses to netrins.