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The role of L-arginine in hypertension and nephrotoxicity
1Department of Medicine, Barnes-Jewish Hospital (North Campus), Washington University School of Medicine, St Louis, MO 63110-1092, USA. sklahr@imgate.wustl.edu
Current Opinion in Nephrology and Hypertension
|November 18, 1998
Abstract:
The L-arginine-nitric oxide pathway appears to play an important role in systemic hypertension, progressive renal disease, nephrotoxicity (lead poisoning), inflammation and atherosclerosis. Interactions of nitric oxide with other systems (renin-angiotensin, endothelins, eicosanoids, cytokines and other regulators of inflammation) have been described. These interactions may be important in disease states.