Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins and the kidney

D C Wheeler1

  • 1Department of Nephrology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. david.wheeler@university-b.wmids.nhs.uk

Current Opinion in Nephrology and Hypertension
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM).

BMC nephrology·2023
Same author

Time-dependent lipid profile inversely associates with mortality in hemodialysis patients - independent of inflammation/malnutrition.

Journal of internal medicine·2021
Same author

The effects of cinacalcet on blood pressure, mortality and cardiovascular endpoints in the EVOLVE trial.

Journal of human hypertension·2015
Same author

Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes.

Kidney international·2007
Same author

NDT contributes to a collection of 100 seminal papers published by Oxford University Press.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2006
Same author

Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.

Tissue antigens·2004
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
Same journal

Advancing science and care in CKD-MBD: the layered path to legacy.

Current opinion in nephrology and hypertension·2026
See all related articles

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) effectively treat dyslipidemia in kidney disease. Emerging evidence shows they also protect against vascular injury and may slow renal failure progression.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Dyslipidemia is a common complication in patients with renal disease.
  • Statins are widely used to manage lipid disorders.
  • Recent research indicates statins may offer benefits beyond lipid lowering in renal patients.

Purpose of the Study:

  • To review the current evidence on the use of statins in nephrology.
  • To explore the pleiotropic effects of statins in renal disease.
  • To assess the potential of statins in managing chronic renal failure and post-transplant immunosuppression.

Main Methods:

  • Review of recent clinical studies and scientific literature.
  • Analysis of data on lipid-lowering effects and non-lipid-mediated actions of statins.

Related Experiment Videos

  • Evaluation of statin efficacy in slowing chronic kidney disease progression and augmenting immunosuppression.

    • Main Results:

    • Statins are safe and effective for treating dyslipidemia in renal disease.
    • Statins demonstrate vascular protective effects independent of lipid reduction.
    • Evidence suggests statins may slow chronic renal failure progression and enhance immunosuppressive therapy post-transplantation.

    Conclusions:

    • Statins offer significant therapeutic advantages in nephrology, extending beyond lipid management.
    • Their pleiotropic effects, including vascular protection and potential renoprotection, warrant further investigation.
    • Statins are likely to find expanded applications in the management of various renal conditions.