Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endometriosis: abnormal endometrium and dysfunctional immune response

D P Braun1, W P Dmowski

  • 1Institute for the Study and Treatment of Endometriosis, Chicago, Illinois, USA.

Current Opinion in Obstetrics & Gynecology
|November 18, 1998
PubMed
Summary

Endometriosis involves the immune system, where resistant endometrial cells use immune responses to grow. Failure to eliminate these cells leads to disease progression and associated immune dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between changes in quality of life scores and survival in non-small cell lung cancer patients.

European journal of cancer care·2012
Same author

Retroperitoneal subpancreatic ectopic pregnancy following in vitro fertilization in a patient with previous bilateral salpingectomy: how did it get there?

Journal of assisted reproduction and genetics·2002
Same author

Apoptosis in endometrial glandular and stromal cells in women with and without endometriosis.

Human reproduction (Oxford, England)·2001
Same author

Postlaparoscopic small bowel obstruction secondary to unrecognized nodular endometriosis of the terminal ileum.

The Journal of the American Association of Gynecologic Laparoscopists·2001
Same author

Cytokine biosynthesis by tumor-infiltrating T lymphocytes from human non-small-cell lung carcinoma.

Cancer immunology, immunotherapy : CII·2000
Same author

Intracytoplasmic sperm injection into zona-free human oocytes results in normal fertilization and blastocyst development.

Human reproduction (Oxford, England)·1999

Area of Science:

  • Immunology
  • Reproductive Biology
  • Cell Biology

Background:

  • Endometriosis is a complex gynecological condition characterized by the presence of endometrial-like tissue outside the uterus.
  • The exact mechanisms driving endometriosis pathogenesis remain incompletely understood, with increasing evidence pointing to immune system involvement.

Purpose of the Study:

  • To review recent research on the immune system's role in endometriosis.
  • To present a model where endometriosis arises from an immunological selection process.

Main Methods:

  • Literature review of recent studies focusing on immunology and endometriosis.
  • Analysis of findings within the proposed immunological selection model framework.

Main Results:

Related Experiment Videos

  • Endometrial cells possess inherent resistance to apoptosis and immune elimination.
  • These cells can exploit activated immune system components to form ectopic lesions.
  • Persistent immune stimulation that fails to clear ectopic implants contributes to disease progression and immune derangement.

Conclusions:

  • Endometriosis may be viewed as a condition resulting from a failure of immune surveillance and elimination.
  • The interplay between endometrial cells and the immune system is critical for disease establishment and progression.
  • Understanding these immunological aspects is key to developing novel therapeutic strategies for endometriosis.