Related Experiment Video
Updated: Aug 15, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
Published on: May 4, 2012
[Pharmacologic importance of glycation of plasma proteins]
Abstract:
A short review provides basic information about the influence of glycation of plasma proteins, as a complication of uncompensated diabetes mellitus, on binding parameters of drugs from various pharmacological groups. There are many facts about the influence of diabetes on binding sites of plasma proteins, but only a relation between the free fraction of sulphonamides and the degree of albumin glycation was described. Observed changes of free fractions of other drugs in diabetic patients are related rather to a competition of these drugs with free fatty acids or other endogenic metabolites for albumin binding sites than to glycation reaction itself. A current clinical status and results of biochemical and pharmacokinetic analyses are necessary for an objective survey of efficiency of pharmacological treatment in diabetic patients.
More Related Videos
06:26Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
Published on: February 14, 2020
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Proteoglycans
Oral Hypoglycemic Agents: Glinides
Dipeptidyl Peptidase 4 Inhibitors
Hyperglycemia
Diabetic Nephropathy