Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

D2 receptor binding in dopa-responsive dystonia

G Künig1, K L Leenders, A Antonini

  • 1PET Program, Paul Scherrer Institute, Villigen, Germany.

Annals of Neurology
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for a Spectral Break or Curvature in the Spectrum of Astrophysical Neutrinos from 5 TeV to 10 PeV.

Physical review letters·2026
Same author

Energy Spectrum of Ultrahigh-Energy Cosmic Rays across Declinations -90° to +44.8° as Measured at the Pierre Auger Observatory.

Physical review letters·2026
Same author

An international 20 country patient and physician survey of the usability and acceptability of Stepped Care pathway in Parkinson's disease.

Scientific reports·2025
Same author

Quantification of plasma APOE4 with a novel automated Lumipulse immunoassay enables the identification of homozygous and heterozygous APOE ε4 carrier status.

Clinica chimica acta; international journal of clinical chemistry·2025
Same author

Search for Extremely-High-Energy Neutrinos and First Constraints on the Ultrahigh-Energy Cosmic-Ray Proton Fraction with IceCube.

Physical review letters·2025
Same author

Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort.

Journal of neural transmission (Vienna, Austria : 1996)·2025
Same journal

Assessing Progression Independent of Relapse Activity in Multiple Sclerosis Using a Patient-Reported Disability Measure and Self-Administered Neuroperformance Outcomes.

Annals of neurology·2026
Same journal

AQP4 and MOG Characterize the Autoantibody Landscape of Checkpoint Blockade-Induced Optic Neuritis.

Annals of neurology·2026
Same journal

Five Issues of Artificial Intelligence in Science: Sailing the Ship of Theseus.

Annals of neurology·2026
Same journal

Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

Annals of neurology·2026
Same journal

Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

Annals of neurology·2026
Same journal

Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

Annals of neurology·2026
See all related articles

Dopa-responsive dystonia (DRD) patients show higher dopamine D2 receptor binding than healthy controls and Parkinson's disease patients. This suggests altered dopamine function or receptor characteristics in DRD, particularly in the caudate nucleus.

Area of Science:

  • Neuroscience
  • Radiology

Background:

  • Dopa-responsive dystonia (DRD) is a movement disorder characterized by clinical improvement with levodopa.
  • Dopamine D2 receptor availability is a key biomarker in neurological disorders affecting the dopaminergic system.

Purpose of the Study:

  • To investigate dopamine D2 receptor binding using [11C]raclopride positron emission tomography in patients with DRD.
  • To compare [11C]raclopride binding in DRD patients with levodopa-treated Parkinson's disease (PD) patients and healthy controls.

Main Methods:

  • Positron emission tomography (PET) imaging with the dopamine D2 receptor radioligand [11C]raclopride.
  • Quantitative analysis of [11C]raclopride binding index in the putamen and caudate nucleus.

Main Results:

Related Experiment Videos

  • DRD patients exhibited an elevated [11C]raclopride binding index in both the putamen and caudate nucleus compared to healthy controls.
  • A significant elevation in [11C]raclopride binding was observed in the caudate nucleus of DRD patients compared to PD patients.
  • Increased binding may indicate reduced endogenous dopamine or altered receptor characteristics in DRD.

Conclusions:

  • The findings suggest altered dopaminergic neurotransmission or receptor dynamics in DRD.
  • The caudate nucleus appears to play a significant pathophysiological role in both DRD and PD.
  • PET imaging with [11C]raclopride can differentiate DRD from PD and healthy controls based on dopamine D2 receptor availability.