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Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli
1Institute for Molecular Biology and Genetics, Seoul National University, Korea.
Molecular & General Genetics : MGG
|November 18, 1998
Abstract:
The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.