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Related Experiment Videos

Embryonic development of the ureter

L A Baker1, R A Gomez

  • 1Division of Pediatric Urology, Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.

Seminars in Nephrology
|November 18, 1998
PubMed
Summary

This review details ureteric bud development, crucial for forming the human kidney and collecting system. It covers anatomical, molecular, and developmental factors, including congenital abnormalities.

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The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2019

Area of Science:

  • Developmental Biology
  • Urology
  • Embryology

Background:

  • The ureteric bud, originating from the Wolffian duct, is essential for metanephros and collecting system formation.
  • Ureteric development involves complex anatomical and molecular processes during human embryonic development.

Purpose of the Study:

  • To review the anatomical and molecular basis of ureteric development.
  • To discuss factors influencing ureteric budding, branching, and maturation.
  • To present congenital abnormalities in ureteral development and their potential mechanisms.

Main Methods:

  • Literature review focusing on ureterogenesis and metanephrogenesis.
  • Analysis of current understanding of embryonic ureter development.
  • Synthesis of data on molecular and anatomical factors.

Main Results:

  • Detailed discussion of the ureteric bud's role in kidney development.
  • Explanation of factors governing ureteric budding, branching, and maturation into a functional conduit.
  • Overview of congenital ureteral abnormalities and proposed causative mechanisms.

Conclusions:

  • Ureteric bud development is a fundamental process in forming the urinary collecting system.
  • Understanding ureteric development aids in diagnosing and potentially treating congenital abnormalities.
  • Further research into the molecular and anatomical factors is needed to fully elucidate ureterogenesis.

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