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Hormonal changes during a 20-week confinement

A Maillet1, J Titze, V Gushin

  • 1Laboratoire de Physiologie de l'Environnement, Faculté de Médecine Lyon Grange-Blanche, France.

Aviation, Space, and Environmental Medicine
|November 18, 1998
PubMed
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Long-term confinement alters volume-regulating hormones, mimicking spaceflight fluid shifts. These hormonal changes, including increased renin and initial urinary volume increases, are crucial for understanding astronaut health during space missions.

Area of Science:

  • Human physiology
  • Space medicine
  • Endocrinology

Background:

  • The European Space Agency's EUROMIR'95 mission involved a long-duration spaceflight simulation.
  • A ground-based confinement experiment, the Human Behaviour Study, was conducted concurrently.
  • This study investigated hormonal changes during a 20-week confinement period.

Purpose of the Study:

  • To analyze changes in volume-regulating hormones during prolonged confinement.
  • To compare ground-based confinement effects with known spaceflight physiological responses.
  • To assess the impact of confinement on cardiovascular and hormonal parameters.

Main Methods:

  • Three subjects were confined in a normobaric diving chamber for 135 days.
  • Measurements included arterial pressure, plasma hormone concentrations (renin, arginine-vasopressin), and urinary variables.

Related Experiment Videos

  • Data were collected before, during, and after the confinement period.

    • Main Results:

    • Arterial pressure increased from week 1 to week 15; heart rate elevated from week 6 onwards.
    • Plasma active renin levels were consistently elevated after week 6 of confinement.
    • A transient increase in urine volume was observed during the first two days of confinement.

    Conclusions:

    • Confinement-induced hormonal changes resemble those seen in weightlessness or head-down tilt.
    • Elevated renin and initial urinary volume increases are key indicators of fluid shifts.
    • Findings are significant for understanding physiological adaptations during spaceflight and bed rest.