Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Yohimbine in neurally mediated syncope. Pathophysiological implications

R Mosqueda-Garcia1, R Fernandez-Violante, J Tank

  • 1The Syncope Service in the Autonomic Dysfunction Unit, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

The Journal of Clinical Investigation
|November 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep Macrostructure, Cyclic Alternating Pattern and CSF Cytokines in De Novo Relapsing-Remitting Multiple Sclerosis: A Controlled Polysomnographic Study.

Journal of sleep research·2025
Same author

Long-duration human spaceflight induces atrophy in the left ventricular papillary muscles.

NPJ microgravity·2025
Same author

'Transient immediate orthostatic hypotension' is preferable to 'initial' orthostatic hypotension.

Autonomic neuroscience : basic & clinical·2025
Same author

Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine.

Hypertension (Dallas, Tex. : 1979)·2024
Same author

Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2024
Same author

Impact of daily artificial gravity on autonomic cardiovascular control following 60-day head-down tilt bed rest.

Frontiers in cardiovascular medicine·2023
Same journal

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
Same journal

Extracellular matrix reprogramming by the YAP/TAZ- TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models.

The Journal of clinical investigation·2026
Same journal

Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer.

The Journal of clinical investigation·2026
Same journal

Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

The Journal of clinical investigation·2026
Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026
Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026
See all related articles

Increased sympathetic activity is not always required for neurally mediated syncope (NMS). Enhancing sympathetic tone with yohimbine prevented syncope in most NMS patients, suggesting a potential treatment.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Neurally mediated syncope (NMS) is a common condition.
  • The role of sympathetic stimulation in NMS development is debated.
  • Tilt-table testing is used to diagnose syncope.

Purpose of the Study:

  • To investigate if increased sympathetic stimulation is essential for neurally mediated syncope (NMS).
  • To evaluate the effect of manipulating sympathetic outflow on tilt-induced syncope.
  • To assess the therapeutic potential of yohimbine in NMS.

Main Methods:

  • Eight NMS patients and eight controls underwent tilt-table tests.
  • Subjects received clonidine (CLO) or yohimbine (YHO) to alter sympathetic tone.
  • Intraarterial blood pressure, EKG, and muscle sympathetic nerve activity (MSNA) were monitored.

Related Experiment Videos

Main Results:

  • All NMS patients experienced syncope during basal tilts.
  • Clonidine (reducing sympathetic tone) decreased tilt tolerance in controls and NMS patients.
  • Yohimbine (increasing sympathetic tone) prevented syncope in 7/8 NMS patients and increased MSNA.

Conclusions:

  • Increased sympathetic activity is not a prerequisite for NMS development.
  • Enhancing sympathetic tone with yohimbine improves orthostatic tolerance in NMS patients.
  • Yohimbine may be a potential therapeutic agent for treating NMS.