Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

beta-Thalassaemia major in Kuwait

L al-Fuzae1, K C Aboolbacker, Q al-Saleh

  • 1Department of Paediatrics, Sabah Hospital Kuwait, Shuwaikh, Kuwait.

Journal of Tropical Pediatrics
|November 20, 1998
PubMed
Summary

This study on beta-thalassaemia major patients in Kuwait found a high rate of consanguineous marriages and significant hepatitis C prevalence. Bone marrow transplantation showed no mortality but had complications like graft rejection and GVHD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Truncal aplasia cutis congenita associated with ileal atresia and mesenteric defect.

Pediatric dermatology·2000
Same author

Peripheral T-cell activation in non-segmental vitiligo.

The Journal of dermatology·1998
Same author

An epidemiologic, clinical, and therapeutic study of childhood Guillain-Barré syndrome in Kuwait: is it related to the oral polio vaccine?

Journal of child neurology·1998
Same author

Febrile urinary tract infection in children: Role of 99MTc-dimercaptosuccinic acid (DMSA) scan and other imaging techniques.

Annals of Saudi medicine·1996
Same author

Right upper limb bud triplication and polythelia, left sided hemihypertrophy and congenital hip dislocation, facial dysmorphism, congenital heart disease, and scoliosis: disorganisation-like spectrum or patterning gene defect?

Journal of medical genetics·1995
Same author

Molecular characterization of alpha-thalassemia determinants, beta-thalassemia alleles, and beta S haplotypes among Kuwaiti Arabs.

Acta haematologica·1994

Area of Science:

  • Hematology
  • Genetics
  • Infectious Diseases

Background:

  • Beta-thalassaemia major is a severe inherited blood disorder.
  • Understanding patient demographics and comorbidities is crucial for effective management.
  • Consanguinity is a known risk factor for recessive genetic disorders.

Purpose of the Study:

  • To analyze the clinical characteristics and outcomes of beta-thalassaemia major patients.
  • To investigate the prevalence of consanguinity and viral hepatitis in this cohort.
  • To evaluate the safety and efficacy of bone marrow transplantation (BMT) in managing beta-thalassaemia major.

Main Methods:

  • A combined retrospective and prospective study design.
  • Inclusion of 129 beta-thalassaemia major patients diagnosed between 1965 and 1995.
  • Data collection on patient demographics, consanguinity, hepatitis B (HBsAg) and C seropositivity, and BMT outcomes.

Main Results:

  • The median age at diagnosis was 9 months (range 2-84 months).
  • Approximately 80% of patients resulted from consanguineous marriages (first- or second-cousin).
  • Hepatitis C seropositivity was observed in 33% of patients, while 7% were HBsAg positive.
  • Of 11 patients undergoing BMT, there was no mortality, but 3 experienced graft rejection and 2 developed chronic graft-versus-host disease (GVHD).

Conclusions:

  • Consanguinity and hepatitis C are significant factors in beta-thalassaemia major patients in Kuwait.
  • BMT is a viable treatment option with no associated mortality, though graft complications require careful monitoring and management.

Related Experiment Videos