[Immunomodulating action of energizing drugs during dosed fasting]

Cessation of nutrient entry suppresses glycogen production in hepatocytes. Triggering of the lipid pathway of energy supply limits carbohydrate utilization because of citrate block development. Fasting involves impairment of erythrocyte structure and membranes, increase of hepatocyte membrane permeability, and decrease of functional activity of lymphocyte population. These changes can be due to glucose deficit in capillaries of lymphoid organs. Study of effects of riboxin, mildronate, glucose, benfothiamine, and their combinations on immune response of rats after 5- of 7-day fasting led the authors to a conclusion that an immunomodulating effect can be induced by combinations of riboxin or mildronate with glucose and benfothiamine.