Related Experiment Video
Updated: Aug 11, 2026

Murine Renal Transplantation Procedure
Published on: July 10, 2009
Renal transplantation in a patient with methylmalonic acidaemia
S C Van Calcar1, C O Harding, P Lyne
1Waisman Center, University of Wisconsin-Madison, USA.
Abstract:
Renal insufficiency is frequently reported in mutase-deficient methylmalonic acidaemia. We present a case report of a patient with mut- methylmalonic acidaemia who developed chronic tubulointerstitial nephropathy during adolescence. At 24 years of age, she developed end-stage renal failure and underwent renal transplantation. Both plasma and urine methylmalonic acid levels decreased significantly with improved renal function following transplantation. Complications included cyclosporin toxicity and development of diabetes. Renal, metabolic, and clinical status remained improved at 3 years after the kidney transplant.
Related Concept Videos
Inborn Errors of Metabolism
Kidney Transplant I: Introduction
Kidney Transplant II: Surgical Procedure
Kidney Transplant III: Nursing Management

