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Vitiligo caused by chloroquine phototoxicity
1Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
Journal of the Royal Army Medical Corps
|November 20, 1998
Summary
Chloroquine prophylaxis for malaria can cause temporary depigmentation in children with atopic eczema. Discontinuing the drug led to complete skin repigmentation within a year.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Atopic eczema is a chronic inflammatory skin condition.
- Chloroquine is an antimalarial drug used for prophylaxis.
Observation:
- A pediatric patient with atopic eczema developed depigmented skin patches after weekly chloroquine use.
- Depigmentation was most prominent on the face, particularly the periorbital area.
Findings:
- Discontinuation of chloroquine therapy resulted in gradual skin repigmentation.
- Complete repigmentation was observed approximately one year after cessation of the drug.
Implications:
- Chloroquine-induced depigmentation is a reversible side effect.
- Clinicians should consider potential skin side effects in patients with pre-existing dermatoses receiving chloroquine.