Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Putting the genome on the map

J M Bridger1, W A Bickmore

  • 1MRC Human Genetics Unit, Edinburgh, UK. joannab@hgu.mrc.ac.uk

Trends in Genetics : TIG
|November 20, 1998
PubMed
Summary
This summary is machine-generated.

Genomic sequencing maps are insufficient for understanding eukaryotes. A comprehensive genome map must include spatial context for chromosome function and gene expression, moving beyond linear sequence data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Compatibility Between Biomphalaria glabrata Snails and Schistosoma mansoni: An Increasingly Complex Puzzle.

Advances in parasitology·2017
Same author

PRC2-independent chromatin compaction and transcriptional repression in cancer.

Oncogene·2014
Same author

Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations.

Biochemical Society transactions·2005
Same author

Do higher-order chromatin structure and nuclear reorganization play a role in regulating Hox gene expression during development?

Cold Spring Harbor symposia on quantitative biology·2005
Same author

Mammalian artificial chromosomes: modern day feats of engineering--Isambard Kingdom Brunel style.

Cytogenetic and genome research·2004

Area of Science:

  • Genomics
  • Molecular Biology
  • Cell Biology

Background:

  • The completion of the first eukaryotic genome sequence (Saccharomyces cerevisiae) and the anticipated human genome sequence mark significant advancements.
  • However, linear genomic sequence maps alone are increasingly recognized as inadequate for fully describing complex eukaryotic genomes.
  • This limitation stems from the growing understanding of the critical role of spatial organization in genome function.

Purpose of the Study:

  • To argue for the necessity of incorporating spatial information into genome mapping.
  • To propose that genome maps should provide a richer, more contextualized representation, analogous to navigational maps.
  • To highlight the inadequacy of purely linear sequence data for understanding eukaryotic chromosome function and gene expression.

Related Experiment Videos

Main Methods:

  • This study is primarily conceptual, involving the critical analysis of existing genomic data representation.
  • It synthesizes current understanding of chromosome structure and gene regulation.
  • It draws parallels between genomic information and navigational mapping principles.

Main Results:

  • Linear genomic sequences, while valuable, do not capture the essential three-dimensional organization of chromosomes.
  • Spatial context is crucial for understanding gene expression regulation and overall chromosome function.
  • Current genomic maps lack the depth of information required for a complete functional understanding.

Conclusions:

  • Future genome mapping efforts must integrate spatial and functional data beyond linear sequences.
  • A more comprehensive understanding of eukaryotic genomes requires maps that reflect their three-dimensional architecture.
  • The development of such advanced genome maps is essential for fields ranging from basic biology to medicine.