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Related Experiment Videos

Chemotherapy and P-glycoprotein expression in chondrosarcoma

R M Terek1, G K Schwartz, K Devaney

  • 1Department of Orthopaedics, Brown University and Rhode Island Hospital, Providence, USA. RICHARD_TEREK@BROWN.EDU

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|November 20, 1998
PubMed
Summary

Dedifferentiated chondrosarcomas show poor survival rates with chemotherapy, with a median survival of 12 months. P-glycoprotein expression is common in these tumors, potentially explaining resistance to chemotherapy.

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Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Chondrosarcomas are often considered chemotherapy-resistant.
  • Dedifferentiated chondrosarcomas represent a challenging subtype with limited treatment options.

Purpose of the Study:

  • To reevaluate the efficacy of chemotherapy in dedifferentiated chondrosarcomas.
  • To investigate the role of P-glycoprotein expression in chemotherapy resistance.

Main Methods:

  • Retrospective review of 18 patients with dedifferentiated chondrosarcomas treated with chemotherapy (cisplatin and doxorubicin).
  • Kaplan-Meier survival analysis.
  • Immunostaining for P-glycoprotein expression in 41 cartilage tumors.

Main Results:

  • Median survival was 12 months for patients treated with chemotherapy.

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  • 37 out of 41 (90%) cartilage tumors, including those from the chemotherapy group, expressed P-glycoprotein.
  • High-grade chondrosarcoma patients treated with chemotherapy had poor survival rates.

    • Conclusions:

    • Chemotherapy offers limited survival benefit for dedifferentiated chondrosarcomas.
    • Widespread P-glycoprotein expression in chondrosarcomas may contribute to their resistance to chemotherapy.
    • Further research into overcoming P-glycoprotein-mediated resistance is warranted.