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Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?
Science (New York, N.Y.)
|November 5, 1976
Abstract:
When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.